Forthcoming Peroxisome meetings 2011

GFPD Family and Scientific Conference

July 31 – August 2, 2011

Omaha, Nebraska

Program

--------------------------------------------------------------------------------------------------------------

Gordon Research Conference

Cell-Cell Fusion

In Sex, Life, Development and Disease

August 7-12, 2011

University of New England

Biddeford, ME

8 August 2011, Monday  

9:10 am - 9:40 am                                                                   

Randy Schekman (UC Berkeley, USA)

"Mechanism of Sorting and Traffic of Peroxisomal Proteins from the ER"

--------------------------------------------------------------------------------------------------------------

International Conference on Plant Peroxisome Research 

satellite meeting to Plant Biology 2011

August 11, 2011

Hilton Minneapolis, Minneapolis, Minnesota, USA

Full program

17 talks, 21 posters and 42 registered researchers..

online registration is available till 11 August 2011 

--------------------------------------------------------------------------------------------------------------

FEBS workshop 2011

Plant Organellar Signalling

from algae to higher plants

Primošten, Croatia

31 August - 3 September 2011

Full program

Peroxisome related talks -

31 August  - Wednesday

Session 2 - ORGANELLE BIOGENESIS AND FUNCTION

12:00 –12:15

OEF18 is a novel calcium binding protein at peroxisomes and chloroplasts

Simon Stael (Uni. Vienna, Austria)

14:00 –14:15

The PEX11 family: Deciphering a key player of peroxisomal proliferation

Friedrich Kragler (MPI-Golm, Germany?)

--------------------------------------------------------------------------------------------------------------

Special Interest Group meeting on Peroxisome biology

Saturday 10 September, 10:00 to 17:15

Part of the Special Interest symposia during EMBO meeting 2011 Vienna, Austria.

Organisation: Ida van der Klei, Marten Veenhuis

12 talks by European peroxisome researchers.

--------------------------------------------------------------------------------------------------------------

9th international conference on AAA proteins

6-10 November 2011

Kumamoto, Japan

09 November 2011

09:00 - 09:30

Ralf Erdmann (Ruhr-Univ. Bochum, Germany)

Functional role of the yeast AAA-peroxins Pex1p and Pex6p in peroxisome biogenesis      

09:30 - 10:00

Yukio Fujiki (Kyushu Univ, Japan)

To be announced

--------------------------------------------------------------------------------------------------------------

New player in ER-Peroxisome field

Peroxisomes proliferate by growth and division as well as they can arise de novo from Endoplasmic reticulum. In yeast, it was recently shown that most PMPs transit to peroxisomes via ER. In mammalian cells, Pex16 and Pex3 are known to target peroxisomes via ER. But the key players involved in this ER-peroxisome transport are still poorly known.

The new study published in PNAS identifies Sec16B as factor essential for Pex16 export from ER to peroxisomes. 

Sec16B is involved in the endoplasmic reticulum export of the peroxisomal membrane biogenesis factor peroxin 16 (Pex16) in mammalian cells

Yonekawa et al, Online published before print on 18 july 2011, PNAS

Sec16B(Sec16S) is a vertebrate specific isoform which is less extensively studied than the Sec61A(Sec16L). Comparing the sizes, Sec16B is almost half the size that of Sec16A and these proteins are able to form heteromeric complexes too.

This study found that, overexpression of Sec16B results in reduced number of peroxisomes and ER localization of Pex16 and Pex3. On the other hand, siRNA mediated knockdown of Sec16B results in tubulated peroxisomes, ER localization of pex16 and degradation of Pex3 by Ubiquitin proteasomal system. Authors also characterized different regions of Sec16B and found that C-terminal of Sec16B which differs from Sec16A, is required for its function in peroxisome biogenesis. Peroxisome vesicle formation from ER is known to be independent of COPII vesicle budding. Sec16A as well as Sec16B are involved formation of COPII vesicles and are targeted to ERES(ER Exit Sites). Authors meticulously shown that, stretch of Sec16B  responsible for its recruitment to ERES is not required for its peroxisome related function.

Further reading

Cell-free sorting of peroxisomal membrane proteins from the endoplasmic reticulum

PNAS, May 2011

A vesicle carrier that mediates peroxisome protein traffic from the endoplasmic reticulum

PNAS, December 2011

Urban planning of the endoplasmic reticulum (ER): How diverse mechanisms segregate the many functions of the ER

BBA Mol Cell Research, in press

Glycosome related abstracts - KMCB 2011

Kinetoplastid Molecular Cell Biology Meeting

Meeting Date: April 8-12, 2011

Woods Hole, MA

Leishmania donovani receptor-cargo protein complexes form in the cytosol and dock at glycosomal protein Peroxin14, modulating its conformation.

The Leishmania donovani glycosomal protein peroxin 14 hydrophobic region is necessary for membrane association

Extra-Glycosomal Localization of Trypanosoma brucei Hexokinase 2

A compensatory mutant of Leishmania major lacking ether lipids exhibits normal growth and neomycin resistance

The role of L. Mexicana Arginase in host infection

New high impact articles - Novel family of stress-protective proteins and pexophagy

A novel family of dehydrin-like proteins is involved in stress response in the human fungal pathogen Aspergillus fumigates

Sak Hoi et al

MBoC in Press, published April 13, 2011

Authors identified two novel proteins DprA and DprB which are important for peroxisome functioning. Both of these proteins when fused to eGFP localize to peroxisomes and cytosol. Dpr mutants exhibit  altered catalase levels and impaired peroxisomal beta-oxidation.

Damaged peroxisomes are subject to rapid autophagic degradation in the yeast Hansenula polymorpha

Zutphen et al

Autophagy (Impact Factor - 6.829)

Volume 7, Issue 8   August 2011

Authors identified the massive peroxisome degradation process resembling both micro and macro-pexophagy using Pex3 fused with temperature sensitive degron sequence at N-terminus.

New review about Mammalian peroxisomal ABC transporters

Mammalian peroxisomal ABC transporters: from endogenous substrates to pathology and clinical significance
Kemp S et al
British Journal of Pharmacology
Impact Factor - 5.2
Wiley Online Library

Accepted article published online on 14 April 2011

Latest peroxisome articles from high impact journal "The Plant Cell"

Two latest articles about plant peroxisomes from journal "The Plant Cell"
Impact Factor - 10.679

Identification of Novel Plant Peroxisomal Targeting Signals by a Combination of Machine Learning Methods and in Vivo Subcellular Targeting Analyses
Lingner T et al.
First Published on April 12, 2011

Arabidopsis ABERRANT PEROXISOME MORPHOLOGY9 Is a Peroxin That Recruits the PEX1-PEX6 Complex to Peroxisomes
Shino Goto et al.
First Published on April 12, 2011

Treat for the eyes

I thought of introducing an additional feature to this research blog by making it semi-informal.
I would extend the blogposts about peroxisomes with suitable interesting and sometimes non-scientific material like pictures suiting the mood of article or useful links, pictures, video etc.

Stunning photography by my friend Rakesh Chandode

"Beauty of plants"

Link to other galleries of eye-catching pics by Rakesh Chandode on National Geogrpahic
http://ngm.nationalgeographic.com/myshot/gallery/150984
http://ngm.nationalgeographic.com/myshot/gallery/251405