Tuesday, August 3, 2010

Updates (1-8 August 2010)

New Paper in Experimental Cell Research (Impact Factor 3.58)
Dynamin-like protein 1 at the Golgi complex: A novel component of the sorting/targeting machinery en route to the plasma membrane
Bonekamp NA et al.
From the group of Prof.M Schrader, Aveiro, Portugal
Sneak Peek - Eukaryotic cell typically contains several single and double membrane bound organelles. To maintain them, cell utilizes specific as well as shared components. Dynamin like proteins like Dnm1, DLP1/Drp1 are involved in membrane dynamics at mitochondria and peroxisomes. the role of Dnm proteins in peroxisome division was recently uncovered. Interesting insights in organelle biology are pouring in these-days which includes the paper on retromer complex (Vps35, Vps26) involvement in mitochondria derived vesicles transport to peroxisomes. There were controversial reports on cellular localisation of DLP1/Drp1 in different cell lines. In this paper, authors dissected the golgi localised DLP1/Drp1 and find a novel function for them beyond the known repertoire of functions at mitochondria and peroxisomes.

There is also one interesting paper recently "A Mutation in the Mitochondrial Fission Gene Dnm1l Leads to Cardiomyopathy" in PLoS Genetics (impact factor ). In this paper authors identify the gene responible for inherited dilated cardiomyopathy (DCM) using heterozygous mouse fibroblasts (Since homozygous mutants die before birth).
Fig.4D from the PLoS Genetics paper
"peroxisomal morphology is altered by the Python mutation"

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New Peroxisome Paper in PLoS ONE
Genome-Wide Analysis of Effectors of Peroxisome Biogenesis
Saleem RA et al
Institute for Systems Biology,
Seattle, Washington, United States of America.

Figure 3. from the paper
Vps52p, Pir3p and YKL015C are novel peroxisome inheritance factors.

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High Impact peroxisome paper in PNAS (impact factor 9.4)
Different functions of the C3HC4 zinc RING finger peroxins PEX10, PEX2, and PEX12 in peroxisome formation and matrix protein import
Jakob Prestelea et al
From the Group of Prof. Dr. Christine Gietl
Technische Universit√§t M√ľnchen
Germany
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High impact Clinical Peroxisome paper in American Journal of Human Genetics (Impact Factor 12.3)
Mutations in the DBP-Deficiency Protein HSD17B4 Cause Ovarian Dysgenesis, Hearing Loss, and Ataxia of Perrault Syndrome.
Pierce SB et al
From the group of Professor Mary-Claire King,
Department of Genome Sciences, University of Washington

Prof.Mary-Claire King is the famous scientist who had identified BRCA1 (breast cancer type 1 susceptibility protein), the human tumour suppressor gene in 1990 at UC Berkeley.
In another pioneering achievement, in this paper Prof. King group report the identification of  the genetic basis for Perrault syndrome (also known as XX gonadal dysgenesis) for the first time. Surprisingly the single gene D-bifunctional protein (DBP) coding for the peroxisomal multi-functional enzyme was found to be mutated leading to reduction in the transcript levels.

1 comment:

  1. The Cycle is complete... Vps36 and Vps26 which are golgi transport components, are shown to be involved in mitochondria and peroxisome communcation. While DLP1/Drp1 which is mitochondrial or peroxisomal component, is now shown to be invovled in Golgi transport... The earth is round. Yes it is!

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