Friday, September 24, 2010

Stories behind Nobel

Christian de Duve alongwith Albert claude and George Palade received Nobel prize in physiology or medicine in 1974 "for their discoveries concerning the structural and functional organization of the cell"

de Duve discovered peroxisomes, the organelle which harbors still some more mysteries about its roles and origin. Here is the video of interview with Christian de Duve from Web of stories. Not just one or two videos but whooping 106 videos on the web of stories website.

Its so inspiring to watch him speaking on different topics. I hope every peroxisome researcher will like to listen to it.

a quote from one of the video
"I'm not a genius, I didn't invent relativity, or discover relativity, I didn't discover the double helix, I'm not a colourful personality like Francis Crick or Jim Watson, Richard Feynman and so on. So, I'm just a rather ordinary person with a slightly out of ordinary experience"

de Duve talking about family background

For next videos visit the web of stories website

Tuesday, September 14, 2010

Update of the week (13-20 September 2010)

New Paper accepted in Hepatology (Impact Factor - 10.84)
Unconjugated bile salts shuttle through hepatocyte peroxisomes for taurine conjugation
Rembacz KP et al
From the group of Klaas Nico Faber

New accepted paper in Journal of Neuroendocrinology (Impact Factor - 3.7)
D-Aspartate Oxidase Localisation in Pituitary and Pineal Glands of the Female Pig
Yamamoto A. et al.
Brief background - DDO (D-aspartate oxidase) is a PTS1 containing peroxisomal protein.

PhD Dissertation by Anca Nenicu
Supervisor - Prof. Dr. Eveline Baumgart-Vogt
Influence of peroxisomes on development, maturation and adult functions of the testis
submitted to Justus-Liebig-Universität Gießen
pdf link
Link posted for academic purposes only.  Please read the associated copyright note on the website

New Paper in PLoS One (Impact Factor - 4.351)
Deficient Liver Biosynthesis of Docosahexaenoic Acid Correlates with Cognitive Impairment in Alzheimer's Disease
Astarita G. et al.
From the group of Prof. Daniele Piomelli
Findings in Brief - peroxisomal D-bifunctional protein activity is reduced in liver leading to impaired DHA biosynthesis in Alzheimer patients.

ABCD1 and ABCD2 are peroxisomal membrane proteins involved in fatty acid transport.
ACOX1 and HSD17B4, are peroxisomal matrix enzymes involved in beta-oxidation functions, both have C-terminal PTS1 signal.

Review in Microbiology Monographs "Structures and Organelles in Pathogenic Protists"
The Glycosome of Trypanosomatids
By Fred R. Opperdoes

Thursday, September 9, 2010

Update of the week (6 September - 13 September 2010)

New Paper in JBC
Conserved and novel functions for Arabidopsis MIA40 in assembly of proteins in mitochondria and peroxisomes
Chris Carrie et al.
From the group of Prof. Jim Whelan
University of Western Australia

New Paper in Journal of Cell Science (JCS, Impact Factor - 6.14)
Koch et al.
From the group of Dr. Cecile Brocard

New Paper in Journal of Inherited Metabolic Disease (Impact Factor 3.6)
An adult onset case of alpha-methyl-acyl-CoA racemase deficiency
Mayo Clinic, USA
Background - AMACR is a peroxisomal protein in humans which contains unusual C-terminal PTS1 (KASL). AMCAR is also localized to mitochondria with N-terminal topogenic signal as characterized by Amery L. et al. Most interestingly AMACR is demonstrated to be Molecular Marker for Prostate Cancer by Jun Luo et al.

New Paper in Biochemical Journal (Impact Factor 5.15)
Ullán RV et al.
From the group of Dr. Juan F. Martín
University of León, Spain

New review in Expert Review of Neurotherapeutics (Impact Factor 2.991)
Phyllis L Faust et al
Columbia University

Poster by Anna Petroni et al. (from 2007 conference)
Metabolism of 8-Iso-PGF2alpha is impaired by CLA in fibroblasts from patients affected by X-ALD
Powerpoint file 
(above links posted for academic purposes only)