Monday, January 24, 2011

2012 Peroxisome talks

Keystone Symposia 
Cell Biology of Virus Entry, Replication and Pathogenesis
March 26 - 31, 2012

March 30, Friday
Talk - 
Peroxisomes, MAVS and Innate Immunity
Jonathan C. Kagan, Boston Children's Hospital, USA 

Link -

Monday, January 10, 2011

Peroxisome related events in 2011

EMBO Conference
Protein Transport Systems
Structures, mechanisms and medical aspects
16 - 20.04.2011, Santa Margherita di Pula, Italy

20:30 - 21:00
Ralf Erdmann
The peroxisomal protein import machinery

17:00 - 17:30
Adabella van der Zan
lluminating the peroxisomal biogenesis pathway

9th international conference on AAA proteins
6-10 November 2011, Kumamoto Japan

9 November 2011
09:00 - 09:30
Ralf Erdmann (Ruhr-Univ. Bochum, Germany)
Functional role of the yeast AAA-peroxins Pex1p and Pex6p in peroxisome biogenesis

09:30 - 10:00
Yukio Fujiki (Kyushu Univ, Japan)
To be announced

Sunday, January 9, 2011

Peroxisomes - Alzheimer's Disease and Hepatitis

Hepatitis B Virus Regulatory HBx Protein Binds to Adaptor Protein IPS-1 and Inhibits the Activation of Beta Interferon
Journal of Virology, January 2011
Kumar M et al.
From the group of Prof. B. L. Slagle
Baylor College of Medicine, Texas
Brief Description -
IPS1 is also known as MAVS (mitochondrial antiviral signaling) protein. Last year it was discovered that MAVS subpopulation also resides on peroxisomes and is responsible for rapid but transient type I-interferon independent antiviral gene expression(Dixit et al, Cell, 2009). It was known that Hepatitis A and Hepatitis C viral proteins target IPS1 to inactivate host innate immune response. This paper establishes that Hepatitis B viral protein HBx also modulates host signalling by targeting IPS1. Since IPS1 also resides on peroxisomes, there arises the possibility of HBV acting at this organelle.

Plasmalogen synthesis is regulated via alkyl-dihydroxyacetonephosphate-synthase (AGPS) by amyloid precursor protein (APP) processing and is affected in Alzheimer’s disease
Grimm et al.
Journal of Neurochemistry, January 2011 (Accepted Article)
Brief Description -
Alkyl-dihydroxyacetonephosphate-Synthase (AGPS) is a PTS2 containing peroxisomal protein involved in ether lipid biosynthesis. Plasmalogen synthesis is also defective in PBDs (Peroxisome Biogenesis Disorders). This paper shows that APP protein in Alzheimer disease regulates AGPS.