Sunday, January 9, 2011

Peroxisomes - Alzheimer's Disease and Hepatitis

Hepatitis B Virus Regulatory HBx Protein Binds to Adaptor Protein IPS-1 and Inhibits the Activation of Beta Interferon
Journal of Virology, January 2011
Kumar M et al.
From the group of Prof. B. L. Slagle
Baylor College of Medicine, Texas
Brief Description -
IPS1 is also known as MAVS (mitochondrial antiviral signaling) protein. Last year it was discovered that MAVS subpopulation also resides on peroxisomes and is responsible for rapid but transient type I-interferon independent antiviral gene expression(Dixit et al, Cell, 2009). It was known that Hepatitis A and Hepatitis C viral proteins target IPS1 to inactivate host innate immune response. This paper establishes that Hepatitis B viral protein HBx also modulates host signalling by targeting IPS1. Since IPS1 also resides on peroxisomes, there arises the possibility of HBV acting at this organelle.

Plasmalogen synthesis is regulated via alkyl-dihydroxyacetonephosphate-synthase (AGPS) by amyloid precursor protein (APP) processing and is affected in Alzheimer’s disease
Grimm et al.
Journal of Neurochemistry, January 2011 (Accepted Article)
Brief Description -
Alkyl-dihydroxyacetonephosphate-Synthase (AGPS) is a PTS2 containing peroxisomal protein involved in ether lipid biosynthesis. Plasmalogen synthesis is also defective in PBDs (Peroxisome Biogenesis Disorders). This paper shows that APP protein in Alzheimer disease regulates AGPS. 

1 comment:

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