Thursday, March 10, 2011

PhD position: Control of peroxisome abundance in metabolic diseases & cancer

Employer : Institute of Cell Biology, ETH Zurich, Switzerland
Website : http://www.cell.biol.ethz.ch
Last date of application : April 15, 2011

Interested applicants should email their CV, short statement of research interests(half page), and names of 2 referees by email to: Werner.kovacs@cell.biol.ethz.ch
Or by using Online application link

Our research interests are on the genetic and biochemical mechanisms underlying the control of peroxisome abundance in metabolic diseases and cancer. Peroxisomes are highly versatile and dynamic organelles whose number, size and function are vastly dependent on the cell type and growth conditions. The abundance of peroxisomes within a cell is dynamically controlled by environmental cues and (patho)physiological conditions. We apply a wide range of experimental cues technologies (e.g. live-cell imaging, RNAi-screening, functional genomics, proteomics, metabolomics) and model disease states in the mouse.

The successful candidate will be enrolled in the Ph.D. Program of the Life Science Zurich Graduate School. The position is located in Science City, the Life Science Campus of ETH Zurich. The research campus offers state-of-the-art facilities for advanced light and electron microscopy, high-throughput, image-based RNAi screening, quantitative proteomics, functional genomics, and computational analysis of large data-sets.

For further scientific information please contact: werner.kovacs@cell.biol.ethz.ch (http://www.cell.biol.ethz.ch/research/krek/group_members/kovacsw/index).

Dr. Werner Kovacs
ETH Zürich
Institute of Cell Biology
Schafmattstrasse 18, HPM F39
CH-8093 Zürich, Switzerland

1 comment:

  1. Peroxisomes in cancer is a very promising topic.
    Here are some interesting papers which hint towards it

    "Renal cell carcinoma and oxidative stress: The lack of peroxisomes" Acta Histochemica, July 2010
    http://dx.doi.org/10.1016/j.acthis.2009.03.003

    "Peroxisomal branched chain fatty acid beta-oxidation pathway is upregulated in prostate cancer" Prostate, 2005
    http://onlinelibrary.wiley.com/doi/10.1002/pros.20177/abstract

    "Impairment of peroxisomal biogenesis in human colon carcinoma" Carcinogenesis, 1999
    http://carcin.oxfordjournals.org/content/20/6/985

    ReplyDelete